Platelet-Derived Growth Factor Three isoforms that bind to two distinct cell surface receptors
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Acta Oncologica
- Vol. 28 (3) , 331-334
- https://doi.org/10.3109/02841868909111202
Abstract
Several isoforms of the platelet-derived growth factor (PDGF) have been identified and purified to date. The functional effects of the PDGF isoforms differ, due to their different interactions with at least two distinct cell surface receptors. Thus, PDGF constitutes an example of an expanding growth factor family, characterized by possibilities for fine-tuned regulation of action. In this manuscript, we describe the structural features of the PDGF isoforms as well as their receptors.Keywords
This publication has 30 references indexed in Scilit:
- Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.Proceedings of the National Academy of Sciences, 1986
- The biology of platelet-derived growth factorCell, 1986
- cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell linesNature, 1986
- A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chainsNature, 1986
- Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growthCell, 1985
- Platelet-derived growth factorMolecular and Cellular Endocrinology, 1985
- Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma VirusScience, 1984
- Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factorNature, 1983
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusNature, 1983