Functional Impairment of Simian Immunodeficiency Virus-Specific CD8+T Cells during the Chronic Phase of Infection
Open Access
- 1 March 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (5) , 2458-2461
- https://doi.org/10.1128/jvi.75.5.2458-2461.2001
Abstract
In an attempt to determine why high frequencies of circulating virus-specific CD8+T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8+lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8+cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8+T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase.Keywords
This publication has 31 references indexed in Scilit:
- HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic FunctionThe Journal of Experimental Medicine, 2000
- Phenotypic Analysis of Antigen-Specific T LymphocytesScience, 1996
- Human Immunodeficiency Virus Type 1 (HIV-1)- and Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte Precursors Exhibit Different Kinetics in HIV-1-Infected PersonsThe Journal of Infectious Diseases, 1996
- Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.The Journal of Experimental Medicine, 1996
- Detection of intracellular cytokines by flow cytometryJournal of Immunological Methods, 1993
- Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.The Journal of Experimental Medicine, 1993
- Cell dysfunction and depletion in AIDS: the programmed cell death hypothesisImmunology Today, 1991
- Selective Defects in Cytomegalovirus- and Mitogen-Induced Lymphocyte Proliferation and Interferon Release in Patients with Acquired Immunodeficiency SyndromeThe Journal of Infectious Diseases, 1985
- Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1985
- Impaired Production of Lymphokines and Immune (Gamma) Interferon in the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1984