Synthesis of 5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3, 4-dihydrocarbostyril Hydrochloride and Its β-Adrenergic Blocking Activity

Open Access

1 January 1976

journal article
research article
Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI

Vol. 96 (5) , 571-577
https://doi.org/10.1248/yakushi1947.96.5_571

Abstract

5-(3-tert-Butylamino-2-hydroxypropoxy)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride, the main metabolite of the new adrenergic .beta.-blocking agent, 5-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydrocarbostyril hydrochloride (Carteolol hydrochloride), was synthesized, and its antagonism against the positive chronotropic and hypotensive actions of isoproterenol was examined in anesthetized dogs. This compound was a little more active than Carteolol hydrochloride.