DIFFERENT WAYS OF USING GRAFT-VERSUS-HOST REACTIVITIES TO ACHIEVE ACCEPTANCE OF RAT SPLEEN ALLOGRAFTS IN THE SAME DONOR-RECIPIENT PAIRING

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Abstract
SUMMARY Spleen allografts from PVG to AGUS rats across a strong Ag-B difference were consistently rejected. However, by conditioning donors or recipients, graft acceptance was met in five groups when the spleens were grafted from (1) PVG to AGUS rats, the recipients being pretreated i.v. with donor cells; (2) PVG to AGUS rats, the donors being pretreated i.p. and s.c. with recipient cells; (3) PVG to AGUS rats, the recipients being irradiated with 100 R on the day of operation; (4) PVG to AGUS rats, the recipients being splenectomized preoperatively; and (5) (PVG X AGUS)F1 to AGUS rats, no modification of donors or recipients. The variety of methods resulting in indefinite acceptance of a fully immunologically competent organ allograft has strengthened the hypothesis that a balanced interaction between graft and host is essential for spleen graft acceptance in this model. It was hypothesised that graft acceptance occurred when graft-versus-host and host-versus-graft reactivities matched each other in strength.

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