Reactions of theophylline, theobromine and caffeine with Fenton's reagent-simulation of hepatic metabolism
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (5) , 617-621
- https://doi.org/10.3109/00498258709043968
Abstract
1. Theophylline and caffeine undergo N-demethylation and hydroxylation by Fenton's reagent to give uric acid derivatives; theophylline is oxidized mainly to 1-methyluric acid. and 1,3-dimethyluric acid and 1-methyluric acid are the major products obtained from caffeine. 2. Theobromine undergoes predominantly N-demethylation to give 7-methyl-xanthine. 3. The nature of the products indicate that these reactions simulate hepatic drug metabolism.This publication has 11 references indexed in Scilit:
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