Convenient Catalytic, Enantioselective Conjugate Reduction of Nitroalkenes Using CuF2
- 30 October 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (24) , 4575-4577
- https://doi.org/10.1021/ol048035h
Abstract
We document the use of a new catalyst system for the enantioselective conjugate reduction of nitroalkenes utilizing commercially available CuF(2) and the bis-phosphine JOSIPHOS as a ligand. This new protocol not only facilitates ready access to a variety of optically active nitroalkanes, but the results provide also new insight into copper-catalyzed reactions. [reaction: see text]Keywords
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