URTICARIA DUE TO SENSITIVITY TO COLD

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Abstract
Attention has recently been drawn to the occasional occurrence of sensitivity to such physical agents as heat, cold or pressure. Patients with such sensitivity react to the local stimulus with an urticarial wheal and may in addition show a general constitutional reaction. Duke1in this country has devoted particular attention to this subject. Cases falling in this category have been reported with increasing frequency, especially in the German literature. Investigation of the mechanism of these reactions has yielded many interesting facts, many of them at marked variance with one another, but the etiology has not yet been determined. Many writers have considered the reaction to be allergic or immunopathologic, others, the result of alteration of the colloidal state of the blood and others, the result of altered mechanism of the central nervous system or of peripheral neurovascular mechanisms. Urbach and Fasal,2impressed with the conflicting mass of data

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