HEAT-STABLE ESCHERICHIA COLI-ENTEROTOXIN - REDUCED ACTION AFTER ADMINISTRATION OF PHENYLBUTAZONE IN INFANT MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 238  (3) , 350-354
Abstract
Heat-stable E. coli enterotoxin was assayed by the method of Dean determining gut weight to body weight ratios in infant mice. The enterotoxic responses were significantly lower than in saline treated controls when phenylbutazone at 20 .mu.g/mouse was administered s.c. 30 min prior to intragastric toxin challenge. The trials were performed with lyophilized culture filtrates of E. coli O 149:K91(B)K88ab(L) and 3 other enterotoxigenic strains, 1 of which was isolated from an outbreak of swine edema disease; the other 2 strains originated from the stools of diseased children.

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