Demonstration of Increased Gonadotrophic Hormone Production in Castrated Mice with Intrasplenic Ovarian Grafts.

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Abstract
Evidence of an increased rate of production of gonadotrophins in castrated mice with intrasplenic ovarian grafts was obtained by means of parabiotic expts. The ovaries of normal mice, placed in parabiosis with female litter mates that were castrated and had an overy grafted into the spleen from 30-50 days previously, averaged 37% heavier than the corresponding ovaries when parabiosis was performed simultaneously with the other operations. The duration of parabiosis ranged from 9-13 and from 11-35 days, in the 2 groups, averaging 11 days in the former, and 17 days in the latter.