Response to Tissue Injury of Lymphoid Tissue Previously Altered by Castration, Thyroidectomy and Thyroid Feeding

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Abstract
Groups of litter-mate rats of the same sex were subjected to tissue injury by injn. of formalin into leg muscles. Some had previously been castrated, some had been thyroidectomized, and some fed thyroid extract, in order to alter the size of lymphoid tissue and produce structural and functional changes in the pituitary. It was found that the altered lymphoid tissue was capable of shrinkage in response to tissue injury just as is the case in the normal animal. Previous evidence indicates that pituitary stimulation of adrenal cortical secretion is responsible for destruction of lymphocytes, and in these expts. it was found that the altered pituitary was apparently capable of this response to tissue injury.