Transient impairment of the adaptive response to fasting in FXR‐deficient mice
Open Access
- 1 July 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (19) , 4076-4080
- https://doi.org/10.1016/j.febslet.2005.06.033
Abstract
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR‐deficient (FXR−/−) and wild‐type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR−/− mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR−/− mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR−/−mice after 6 h of fasting and was decreased in FXR−/−hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.Keywords
This publication has 17 references indexed in Scilit:
- The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding TransitionJournal of Biological Chemistry, 2005
- Regulation of Carbohydrate Metabolism by the Farnesoid X ReceptorEndocrinology, 2005
- The Farnesoid X Receptor (FXR) as Modulator of Bile Acid MetabolismReviews in Endocrine and Metabolic Disorders, 2004
- Impaired Tricarboxylic Acid Cycle Activity in Mouse Livers Lacking Cytosolic Phosphoenolpyruvate CarboxykinaseJournal of Biological Chemistry, 2004
- Bile Acids Regulate Gluconeogenic Gene Expression via Small Heterodimer Partner-mediated Repression of Hepatocyte Nuclear Factor 4 and Foxo1Journal of Biological Chemistry, 2004
- Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXRGenes & Development, 2004
- Coordinated Control of Cholesterol Catabolism to Bile Acids and of Gluconeogenesis via a Novel Mechanism of Transcription Regulation Linked to the Fasted-to-fed CycleJournal of Biological Chemistry, 2003
- Acute Inhibition of Hepatic Glucose-6-phosphatase Does Not Affect Gluconeogenesis but Directs Gluconeogenic Flux toward Glycogen in Fasted RatsPublished by Elsevier ,2001
- REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSIONAnnual Review of Biochemistry, 1997
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969