CD4 + CD25 + T-Cell Production in Healthy Humans and in Patients with Thymic Hypoplasia
Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 9 (5) , 1129-1131
- https://doi.org/10.1128/cdli.9.5.1129-1131.2002
Abstract
Regulatory T cells are found primarily in the CD4 + CD25 + fraction of T cells and play an important role in the prevention of autoimmunity. We examined CD4 + CD25 + T cells in 33 healthy children and adults and compared them to a population with an inherited form of thymic hypoplasia and a predisposition to autoimmune disease. Absolute numbers of CD4 + CD25 + T cells were markedly higher in healthy infants than in infants with chromosome 22q11.2 deletion syndrome.Keywords
This publication has 7 references indexed in Scilit:
- Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome)The Journal of Pediatrics, 2001
- Regulatory T cells in the control of immune pathologyNature Immunology, 2001
- CD4+CD25high Regulatory Cells in Human Peripheral BloodThe Journal of Immunology, 2001
- Certified ProfessionalsThe Journal of Experimental Medicine, 2001
- Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideNature Immunology, 2001
- Lack of Correlation between Impaired T Cell Production, Immunodeficiency, and Other Phenotypic Features in Chromosome 22q11.2 Deletion Syndromes (DiGeorge Syndrome/Velocardiofacial Syndrome)Clinical Immunology and Immunopathology, 1998
- Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.The Journal of Experimental Medicine, 1996