Abstract
Unlike the machine, the activity of the living organism is regulated from within. Its metabolism from hour to hour and from day to day proceeds in a manner largely independent of the supply of nutritive materials. Because of this inherent quality of the organism, its structure is injured when it is unable to obtain materials at the rate at which they are utilized or excreted. It may also be harmed when the intake of certain materials is excessive. But the degree of injury and the rate of its development vary greatly with the type of deprivation or excess. It is a matter of only half a century since the importance of this point of view began to be realized. Then abruptly under the leadership of Carl Voit there was initiated a detailed study of the dietary requirements of the normal adult. Even though the problem is

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