Protective Effect of Riboflavin on the Toxicity of 2-Acetylaminofluorene in Rats.

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Abstract
The carcinogen, 2-acetylaminofluorene, produced a riboflavin deficiency in rats, characterized by the appearance of skin lesions and a reduction of liver riboflavin below control values. Increasing the riboflavin content of the diet prevented the appearance of the lesions and maintained a normal content of vitamin in the liver. The increased riboflavin, however, did not prevent the deficiency when the rats were fed a protein-free diet.