Dyphylline Elimination Kinetics in Lactating Women: Blood to Milk Transfer

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Abstract
A population of 20 normal lactating females between the ages of 20 and 35 years was treated with a single 5 mg/kg intragluteal dose of dyphylline, 7‐(2,3‐dihydroxypropyl)theophylline. The distribution of the drug between blood and milk and its pharmacokinetics of elimination were determined. The apparent volume of distribution (Vd) of dyphylline was found to be 0.505 ± 0.162 l./kg, the elimination rate constant (kel) was 0.228 ± 0.055 hr−1, the biological half‐life (t1/2) was 3.21 ± 0.76 hr, and the total body clearance (Cl) was 0.109 ± 0.036 l./kg/hr. The ratio described by dyphylline distribution between milk and serum (M/S) was 2.08 ± 0.52. The elimination rate from milk was equivalent to that from blood.

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