EFFECTS OF RATE OF STIMULATION AND OF FATIGUE ON THE RESPONSE TO NEUROMUSCULAR BLOCKING AGENTS
Open Access
- 1 June 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (2) , 138-143
- https://doi.org/10.1111/j.1476-5381.1958.tb00208.x
Abstract
The response to neuromuscular blocking agents, as exemplified by suxamethonium and tubo-curarine, may differ between symmetrical muscles. Increased rates of stimulation and fatigue both increase sensitivity to blocking agents. During recovery from suxamethonium block muscles may show a transitory failure to react to each stimulus with a contraction. Fatigue caused by prolonged indirect stimulation is prevented equally well by suxamethonium and tubocurarine in doses producing a complete block. The mechanism and significance of these findings are discussed.Keywords
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