PHYSICOCHEMICAL CHARACTERISTICS OF IME - INHIBITOR OF INTERFERON ACTIVITY FROM MOUSE EMBRYO TISSUES

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 25  (5) , 663-668
Abstract
The inhibitor of interferon activity (IME) isolated from mouse embryo tissue was studied. The physicochemical properties of the interferon antagonist were reported. It is not dialysable, not sensitive to trypsin, lysozyme, hyaluronidase, RNase and pH 2, but is sensitive to pH 10 and neuraminidase. Concentrated and partially purified tissue IME was separated on a column with Sephadex G 100. Three distinct, well separated fractions showing antiinterferon activity were obtained. The characteristics and MW of each of these fractions were determined.

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