Template-directed synthesis of oligoadenylates catalyzed by Pb2+ ions
- 1 September 1979
- journal article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 13 (3) , 203-214
- https://doi.org/10.1007/bf01739480
Abstract
The Pb2+ ion is an effective catalyst for the template-directed condensation of ImpA on poly(U). This reaction generates up to 35% of oligomers 5 or more units long. Furthermore, the product is predominantly 3′–5′-linked (75%) unlike that from the uncatalyzed reaction which is more than 90% 2′–5′-linked. The significance of metal-ion catalysis for prebiotic polynucleotide formation is discussed.Keywords
This publication has 10 references indexed in Scilit:
- The role of divalent cations in the mechanism of enzyme catalyzed phosphoryl and nucleotidyl transfer reactionsPublished by Springer Nature ,2007
- The catalysis of nucleotide polymerization by compounds of divalent leadJournal of Molecular Evolution, 1979
- Studies of oligoadenylate formation on a poly(U) templateJournal of Molecular Evolution, 1979
- Preferential formation of (2'–5')-linked internucleotide bonds in non-enzymatic reactionsTetrahedron, 1978
- Catalysis of internucleotide bond formation by divalent metal ionsJournal of the American Chemical Society, 1976
- Oligonucleotide synthesis catalyzed by the zinc(2+) ionJournal of the American Chemical Society, 1975
- Prebiotic chemistry and nucleic acid replicationAccounts of Chemical Research, 1974
- Interaction of metal ions with polynucleotides and related compounds. XXI. Metal ions as agents for the stacking of nucleotides. Specific interaction of zinc(II) and adenosine monophosphateJournal of the American Chemical Society, 1972
- Carbodiimides. VIII.1 Observations on the Reactions of Carbodiimides with Acids and Some New Applications in the Synthesis of Phosphoric Acid EstersJournal of the American Chemical Society, 1958
- Some properties of enzymatically produced polynucleotidesJournal of Polymer Science, 1958