Differential Stimulation of Uterine Cells by Nafoxidine and Clomiphene: Relationship Between Nuclear Estrogen Receptors and Type II Estrogen Binding Sites and Cellular Growth1

Publisher Website
Google Scholar
Abstract
The effects of estradiol, nafoxidine, and clomiphene on uterine histology and nuclear type I and type II estrogen binding sites were examined 96 h following administration of these compounds to mature-ovariectomized rats by beeswax implant. Histological examination revealed that estradiol treatment resulted in dramatic stimulation of the luminal epithelium, stroma, and myometrium. Clomiphene and nafoxidine treatment resulted in intense stimulation of the luminal and glandular epithelium; however, these compounds were only partial agonists in the stroma and myometrium. Increases in uterine wet weight and DNA content correlated with this differential cell stimulation.