Selective p-Toluenesulfonylation of myo-Inositol Derivatives

Abstract
Attempt to know the reactivities, toward sulfonylation, of the hydroxyl groups in myo-inositol was carried out using partially sulfonylated derivatives of myo-inositol. The present studies indicated that the order of reactivity of the hydroxyl groups is 1-OH and 3-OH>4-OH and 6-OH>5-OH>2-OH. From a preparative standpoint, 1,3–di-O-p-toluenesulfonyl-myo-inositol was readily obtained in 59% yield from 1-O-p-toluenesulfonyl-myo-inositol by a selective sulfonylation.

This publication has 3 references indexed in Scilit: