Persistence of Cytoplasmic Differentiation during Mitosis

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Abstract
The general conclusion of Berrill and Huskins (1936) that there is considerable evidence that cell structures and form can only be developed during the inter-kinetic phase of the nucleus is probably justified, but their further generalization that during mitosis such features are lost and are reformed only when the daughter nuclei are reconstituted, does not find adequate support in even a cursory survey of the observations on the behavior of the dividing cell. It appears that progressive differentiation, without any regression, can occur in maturing cells which multiply by mitosis and that in mature cells relatively permanent cytoplasmic structures as epitheliofibrillae, myo-fibrillae, brush borders and specific granulations, as in blood cells and cells of the anterior pituitary gland, may persist during mitosis. The evidence on the possible persistence of the functional capacity of the cell during such activity is much less conclusive.