Aspirin and other anti-inflammatory drugs
Open Access
- 1 October 2000
- Vol. 55 (90002) , 3S-9
- https://doi.org/10.1136/thorax.55.suppl_2.s3
Abstract
Felix Hoffman was a young chemist working at Bayer. Legend has it that his father, who was taking salicylic acid to treat his arthritis, complained to his son about its bitter taste. Felix responded by adding an acetyl group to salicylic acid to make acetylsalicylic acid. Heinrich Dreser, the Company's head of pharmacology, showed it to be analgesic, antipyretic, and anti-inflammatory.3 Bayer introduced the new drug as “aspirin” in 1899 and sales have increased ever since.Keywords
This publication has 77 references indexed in Scilit:
- CYCLOOXYGENASES 1 AND 2Annual Review of Pharmacology and Toxicology, 1998
- Compensatory Prostaglandin E2 Biosynthesis in Cyclooxygenase 1 or 2 Null CellsThe Journal of Experimental Medicine, 1998
- Up‐regulation of cyclooxygenase‐2 mRNA in the rat spinal cord following peripheral inflammationFEBS Letters, 1996
- Safety of Meloxicam: A Global Analysis of Clinical TrialsRheumatology, 1996
- Nimesulide in the Treatment of Patients Intolerant of Aspirin and other NSAIDsDrug Safety, 1996
- A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin productionGastrointestinal Endoscopy, 1995
- Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase IINature, 1995
- Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissuesFEBS Letters, 1993
- Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formationBiochemical and Biophysical Research Communications, 1989
- The pathophysiology of bronchial asthma and targets for its drug treatmentInflammation Research, 1986