Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
- 1 March 1988
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 332 (6159) , 35-40
- https://doi.org/10.1038/332035a0
Abstract
In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell alpha/beta receptor repertoire, including nearly all receptors that use V beta 8.1. The presence of Mlsa/MHC during T-cell development results in the deletion of T cells that express V beta 8.1, documenting the importance of clonal deletion in establishing tolerance to self antigens.Keywords
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