THE EFFECTS OF INTRACISTERNAL SARIN AND PYRIDINE‐2‐ALDOXIME METHYL METHANESULPHONATE IN ANAESTHETIZED DOGS

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Abstract
Dogs poisoned by the anticholinesterase sarin could be saved by intravenous administration of atropine sulphate together with a suitable oxime. The central effects of intracisternal sarin were respiratory paralysis and vasomotor stimulation. The problem arose as to whether the oxime, being a quaternary nitrogen compound, could enter the brain from the blood, and could have a central action on the paralysed respiration. The methyl methanesulphonate of pyridine‐2‐aldoxime administered intracisternally, after sarin poisoning by the same route, was ineffective; atropine, given intravenously, was effective. The central and peripheral effects of sarin were thus reversed by the atropine‐oxime therapy, the central effects by atropine, the peripheral by the oxime.