Effect of Enzyme Inhibitors on Transformation of Enzymes in the Living Cell

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Abstract
The formation of the adaptive enzyme galactozymase in Saccharomyces carlsbergensis is considered as an example of enzyme synthesis. The effect of several known inhibitors on adaptation is examined. Among these, the effect of sodium azide is distinctive: it prevents adaptation from occurring, but does not inhibit (or even stimulates) galactose fermentation after adaptation is complete. It is inferred that the effect of azide on adaptation must therefore be an interference with the formation of a new enzyme or enzyme system, which is in agreement with the known effects of azide on growth and assimilation.