Tryptophol-induced change in brain 5-hydroxytryptamine metabolism
- 1 August 1980
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 69 (3) , 243-246
- https://doi.org/10.1007/bf00433089
Abstract
The effects of tryptophol (TOL) on brain 5-hydroxytryptamine (5-HT) metabolism were studied. After TOL injection (200 mg/kg IP), brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were increased, 5-HT synthesis rate was decreased, and monoamine oxidase (MAO) activity remained unchanged. Pretreatment of mice with p-chlorophenylalanine (PCPA), a potent inhibitor of 5-HT synthesis, did not affect the anticonvulsant action of TOL. These results suggest that alteration of 5-HT metabolism after TOL injection is not directly related to the anticonvulsant action of TOL.Keywords
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