Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
- 1 April 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 290 (5806) , 475-480
- https://doi.org/10.1038/290475a0
Abstract
Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas [in birds] have provided strong evidence that, in most tumors, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. As a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.This publication has 68 references indexed in Scilit:
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