FAILURE OF SOMATOSTATIN TO INHIBIT TOLBUTAMIDE-INDUCED INSULIN SECRETION IN PATIENTS WITH INSULINOMAS: A POSSIBLE DIAGNOSTIC TOOL
- 1 June 1975
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 40 (6) , 1121-1124
- https://doi.org/10.1210/jcem-40-6-1121
Abstract
The effects of somatostatin on tolbutamide-stimulated insulin release were studied in 4 patients with insulin-producing tumors of the pancreas and in 6 normal subjects, in contrast to its effective inhibition of insulin release in normal subjects, somatostatin, without exception, failed to inhibit tolbutamideinduced insulin release in the patients with pancreatic £-cell tumors. This differential effect of somatostatin may prove useful in the diagnosis of insulin-producing tumors of the pancreas.Keywords
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