Studies on Anti-inflammatory Agents. XLVI : Studies on the Synthesis and Analgesic-Anti-inflammatory Activities of Phenylacetic Acid Derivatives bearing Heteroaromatic Rings

Open Access
Publisher Website
Google Scholar
Abstract
A series of phenylacetic acid and phenethyl alcohol derivatives with a bicyclic heteroaromatic ring were synthesized. Bicyclic heteroaromatic rings were imidazo[1,2-a]-pyridine, imidazo[2,1-b]thiazole, imidazo[1,2-a]pyrimidine and indolizine. These compounds were tested for analgesic and anti-inflammatory activity in the phenylquinone writhing [mouse] and carrageenin paw edema [rat] assays, and the relationship between their structure and activity was discussed. 2-[4-(Imidazo[1,2-a]-pyridin-2-yl)phenyl]propionic acid had the most potent activity.