Complexation of tetracylines with metal ions in relation to photosensitization
- 1 March 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (3) , 153-156
- https://doi.org/10.1111/j.2042-7158.1984.tb06929.x
Abstract
It has been shown by spectroscopy and by a Photosensitive Index method, involving measurements of interfacial tension, that Cu2+ and Ni2+ form 2:1 complexes with oxytetracycline and 1:1 complexes with demethylchlortetracycline, Fe2+, Zn2+, Mg2+ and Ca2+ form weaker 1:1 complexes with both drugs. The possibility is discussed of using metal ions to reduce photosensitization by tetracyclines in-vivo.This publication has 17 references indexed in Scilit:
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