POLYCLONAL ORIGIN OF RHEUMATOID SYNOVIAL T-LYMPHOCYTES
- 1 January 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 31 (1) , 55-57
- https://doi.org/10.1093/rheumatology/31.1.55
Abstract
Nineteen T-cell clones from seven patients with RA were obtained by cloning infiltrating lymphocytes from needle synovial biopsies. Southern blot analysis of the T-cell receptor (TCR) β-chain genes in these clones revealed that there were no T-cell clones with an identical rearrangement of the TCRβ gene. These results do not support the idea that the infiltrating T-lymphocytes in RA are of monoclonal or oligoclonal origin.Keywords
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