MANGANESE INDUCED MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN THE BRAIN OF IRON DEFICIENT RATS

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Abstract
Rats were rendered iron deficient by maintaining them on iron deficient diet. Manganese chloride (15 mg/kg) was administered intraperitoneally daily for 15 days to these rats. Morphological studies in the brain tissue showed neuronal degener-ation scattered in the cerebral cortex. Manganese produced marked enzymic alter-ations in the brain of iron deficient rats as compared to similar treatment to rats fed on normal diet. Marked morphological and enzymic alterations in the brain of manganese treated iron deficient rats appear to be due to greater accumulation of the metal in brain tissue of these animals as compared to controls. It may, therefore, be suggested that workers in manganese industry should be checked frequently for iron deficiency as a prophylactic measure.

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