INDUCTION OF ANTI-GLOMERULAR BASEMENT-MEMBRANE ANTIBODIES IN BROWN-NORWAY RAT BY MERCURIC-CHLORIDE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 28  (1) , 173-179
Abstract
The existence of anti-GBM [glomerular basement membrane] antibodies induced by HgCl2 was suspected because of the immunofluorescent linear pattern. It was proved because eluted antibodies from kidneys and circulating Ig[immunoglobulin]G had an anti-GBM activity. A GBM antigen modified by HgCl2 is probably responsible for the appearance of such antibodies. The previous demonstration of the occurrence of an immune complex type glomerulonephritis in outbred Wistar rats (under the same experimental conditions) suggests the existence of a genetic control for this type of immune response.