Association of hypoglycemia and pancreatic islet tissue with micromelia in Malathion-treated chick embryos

Publisher Website
Google Scholar
Abstract
Chick embryos were given a teratogenic dose of Malathion at the 5-day incubation stage and the effects of this treatment on leg length, blood glucose, and amounts of pancreatic islet tissue were studied during the 11- to 19-day incubation period. The Malathion caused a reduction in leg length (micromelia) and hypoglycemia, which persisted throughout the period studied. The severity of the micromelic condition correlated with the degree of hypoglycemia: the least micromelic embryos were the least hypoglycemic, the moderately micromelic embryos were moderately hypoglycemic, and the severely micromelic embryos were the most severely hypoglycemic. Finally, the Malathion increased differentiation of pancreatic islet tissue, particularly beta tissue. Again, the greatest increases in islet tissue were shown by those embryos exhibiting the most severe micromelic and hypoglycemic conditions.

This publication has 2 references indexed in Scilit: