Synthesis and antiviral activities of carbocyclic oxetanocin analogues.
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (10) , 2719-2725
- https://doi.org/10.1248/cpb.38.2719
Abstract
9-Cyclobutyladenine (4a), cis- and trans-9-[3-(hydroxymethyl)cyclobutyl]adenine (4b) and 9-[3,3-bis(hydroxymethyl)cyclobutyl]adenine(4d) were prepared from the corresponding cyclobutylamine derivatives (1a, 1b and 1d). Guanine congeners (9a, cis- and trans-9b and 9d) and carbocyclic oxetanocin G (1'',2''-trans-9f) were also prepared. Carbocyclic oxetanocin A(1'',2''-trans-4f), the preparation of which we have already published, and G were found to be active against herpes simplex virus (type 1 and 2) in vitro, while cis-4b and cis-9b showed an in vitro antiretroviral activity against human immunodeficiency virus (type 1).This publication has 5 references indexed in Scilit:
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