Purine Analogs as Feedback Inhibitors.

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Abstract
Accumulation of ribotide of 5-amino-4-imidazole carboxamide (AICAR), excreted in the riboside form by a purine-requiring mutant of Escherichia coli, was inhibited by a number of structural analogs of purines. The most potent inhibitors were 6-thioguanine, 6-mercaptopurine, and 2,6-diaminopurine. The type of inhibition obtained suggests that the antimetabolites sufficiently resemble natural purines in structure to act as feedback inhibitors in biosynthetic control.

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