Freeze-fracture faces of the perineurial sheath of the rabbit sciatic nerve

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Abstract
Replicas of the perineurium of rabbit sciatic nerve fascicles show extensivezonulae occludentes between the flattened cells of each perineurial lamella. The junctions formed by thezonulae occludentes are of the morphologically ‘tight’ type. Therefore, they are likely to represent the anatomical site of the diffusion barrier previously demonstrated by other morphological and physiological methods. Neighbouring perineurial lamellae are connected to one another by numerousmaculae occludentes, some of which lie on the lateral processes of the perineurial cells. Within the meshes of themaculae occludentes and close to them, small gap junctions can be observed.