Role of nerve pathways in the hypoxic vasoconstriction of lung.

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Abstract
In an earlier paper the author offered support for the postula-tion of a reflex mechanism causing hypoxic pulmonary vasoconstriction. Using similar exised lobe techniques, but with the addition of electrical stimulation of the autonomic nerves at the hilum, it has been possible to differentially suppress hypoxic and neurogenic vasoconstriction by several maneuvers. The latter include hypothermia, pH alteration, short periods of anoxia, local anesthetics, and sympatholytic drugs. The differential suppression of hypoxic and neurogenic vasoconstriction implies that hypoxic pulmonary vasoconstriction is a response not medicated along nerve pathways.

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