Platelet Cholesterol Content and Platelet Aggregation

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Abstract
To the Editor: Stuart et al. have suggested that the increased aggregation of cholesterol-rich platelets1 2 3 is a consequence of enhanced release of arachidonic acid from phospholipids and its increased conversion to thromboxane B2 (the stable end product of thromboxane A2, a potent stimulator of platelet aggregation). Their proposal is attractive.Platelet arachidonic acid is asymmetrically distributed among the inner and outer leaflet of the plasma membrane and granular fractions and among the individual phospholipid classes.4 , 5 This asymmetry may be physiologically important since several recent studies suggest that the site of release of arachidonic acid influences platelet aggregation . . .

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