Synthesis of 2,4,5-Triphenyl-Substituted Oxazolidine and 2,5-Diphenyl-Substituted Pyrrolidine Derivatives

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Abstract
A simple one-pot domino reaction procedure for the stereoselective synthesis of oxazolidines and C 2-symmetric pyrrolidines from inexpensive starting materials is described. Azomethine ylides generated in situ by heating a mixture of benzaldehyde and benzylic amines are trapped with dipolarophiles by a 1,3-dipolar cycloaddition reaction. The products represent valuable synthetic building blocks or potential starting materials for the preparation of chiral auxiliaries and are difficult to obtain by other methods.

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