THE PROXIMAL TUBULAR HANDLING OF AMINO ACIDS AND OTHER NINHYDRIN-POSITIVE SUBSTANCES

Publisher Website
Google Scholar
Abstract
The proximal tubular handling of a number of endogenous ninhydrin-positive substances in the dog was assessed by comparing the clearances of these substances following the injection of an area-specific nephrotoxin into one kidney, with the contralateral uninjected kidney serving as the control.The upper portion of the proximal tubule was primarily responsible for the reabsorption of most of the amino acids and certain other ninhydrin-positive substances. The lower portion of the proximal tubule seems to possess some secretory function (for cystine, lysine, glutamic acid, glutamine, and an unknown substance) and a fair degree of reabsorptive capacity for most of the amino acids.