Vascular endothelial growth factor and its receptors in multiple myeloma
- 26 September 2003
- journal article
- review article
- Published by Springer Nature in Leukemia
- Vol. 17 (10) , 1961-1966
- https://doi.org/10.1038/sj.leu.2403076
Abstract
Multiple myeloma (MM) progresses from an avascular to a vascular phase (active MM) accompanied by a significant increase in microvessel density in the bone marrow. This article summarizes the literature concerning the specific role played by vascular endothelial growth factor (VEGF) in this process. Recent applications of antiangiogenic agents that interfere with VEGF signaling and block MM progression are also described.Keywords
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