The Value of Platelet‐Associated IgG in Predicting the Efficacy of Splenectomy in Autoimmune Thrombocytopenia

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Abstract
In a prospective study, the hypothesis of whether the quantitative determination of platelet-associated IgG (PAIgG) in patients with chronic autoimmune thrombocytopenic purpura (ATP) can predict the efficacy of splenectomy was investigated. PAIgG levels were repeatedly determined in 16 patients with definite ATP pre- and postsplenectomy, and related to platelet counts and platelet mean life span. Patients with an immediate remission after splenectomy tended to have lower PAIgG levels (< 6%) than failures, but this difference was not statistically significant. PAIgG is apparently of limited value for the prediction of the efficacy of splenectomy in ATP.

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