SPONTANEOUS, GONADOTROPIN-RELEASING HORMONE-INDUCED, AND PROGESTERONE-INHIBITED PULSATILE SECRETION OF HUMAN CHORIONIC GONADOTROPIN IN THE FIRST TRIMESTER PLACENTA IN VITRO

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Abstract
Using a multichannel superfusion apparatus, the secretion of human chorionic gonadotropin (hCG) was measured at 1–6 minute intervals in placental explants at 7–9 weeks of gestation. hCG was found to be secreted in distinct pulses (4–5 fold above baseline) every 11–23 minutes peak to peak. Addition of one minute pulses of GnRH analog significantly increased, whereas pulses of progesterone decreased, pulsatile hCG secretion.