Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria
Open Access
- 1 June 1997
- journal article
- review article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 17 (3) , 259-272
- https://doi.org/10.1023/a:1027328510931
Abstract
Recently, we proposed a hypothetical model of coexistence of “Reactive oxygen cycle” with Q cycle and H+ cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane. This review presents a more detailed description of this model and summarizes the supporting experimental evidence obtained.Keywords
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