InsP3‐ and Ca2+‐induced Ca2+ release in single mouse oocytes
Open Access
- 26 November 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 275 (1-2) , 213-216
- https://doi.org/10.1016/0014-5793(90)81474-3
Abstract
To better understand the mechanism of intracellular Ca2+ mobilization, mouse oocytes were micro-injected with ‘caged’-inositol-1,4,5 trisphosphate (caged-InsP3) together with the Ca2+ indicator Fluo-3 ??? and monitor Ca2+ redistribution. Photo-released InsP3 olicits [Ca2+], changes exhibiting several kinetics phases and threshold ??? oscillations were induced after a single InsP3 pulse. Autoregenerative Ca2+ transients could also be induced by injections of Ca2+ itself, demonstrating unequivocally the presence of a Ca2+-induced Ca2+-release mechanism in these cells.Keywords
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