Yeast N‐glycanase distinguishes between native and non‐native glycoproteins
Open Access
- 9 January 2004
- journal article
- Published by Springer Nature in EMBO Reports
- Vol. 5 (2) , 201-206
- https://doi.org/10.1038/sj.embor.7400066
Abstract
N ‐glycanase from Saccharomyces cerevisiae (Png1) preferentially removes N ‐glycans from misfolded proteins. The ability of Png1 to distinguish between folded and misfolded glycoproteins is reminiscent of substrate recognition by UDP‐glucose glycoprotein glucosyl transferase, an enzyme that possesses this trait. The only known in vivo substrates of Png1 are aberrant glycoproteins that originate in the endoplasmic reticulum, and arrive in the cytoplasm for proteasomal degradation. The substrate specificity of Png1 is admirably suited for this task.Keywords
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