Experimental Studies on the Dysfunction of the Urinary Bladder Due to Diabetes Mellitus

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Abstract
Cystometric examinations were done in 20 dogs with alloxan diabetes of 7-300 days duration. In 5 cases abnormal findings were noted on the cystometrogram. Of these 5 cases, one case showed a moderate increase of the intravesical pressure and autonomous cystometrogram, while other 4 cases revealed a hypotonic bladder. In 20 cases the nerves innervating the bladder were examined histologically. In 6 cases of them the degeneration of the myelinated fibers was revealed. The degeneration occurred most commonly in the small- and medium-sized myelinated fibers. The presence of degenerated myelinated fibers was proved in the pelvic nerve in 5 cases which showed an abnormal findings on the cystometrogram. Hence, it is assumed from these findings that the vesical dysfunction due to diabetes mellitus is originated from the lesions of the nerves controlling the bladder.

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