Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors
- 1 April 1991
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 77 (4) , 535-538
- https://doi.org/10.1111/j.1365-2141.1991.tb08622.x
Abstract
Summary. The source of human factor VIIII (FVIII) had a marked effect on the inhibitory activity of a panel of eight human FVIII inhibitors. Use of conventional FVIII concentrates gave lower inhibitor titres whereas a monoclonal antibody purified FVIII concentrate gave titres similar to or greater than those with plasma. Addition of phospholipid (PL) protected highly purified FVIII against inhibition. The content of PL-bound FVIII in concentrates may account for the observed differences.Keywords
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