STUDIES ON DIGESTIVE GROUPS

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Abstract
SUMMARY Randomly bred rabbits were investigated for the influence of the digestive A alloantigen-alloantibody system on skin allotransplantation. The results of the first-set single allografts exchanged between 134 rabbits divided into four series in regard to their digestive group type show a similar survival time of the grafts (8.5 ± 1 days) in the three combinations: A(+) donors to A(+) recipients, A(-) donors to A(-) recipients, and A(-) donors to A(+) recipients. In the only combination of A(+) donors to A(-) recipients, the survival time was shorter (5.5 ± 1 days), the difference between this series and the three other ones being highly significant (P<0.001). In A(-) recipients receiving at the same time grafts from A(+) and A(-) donors, the A(+) grafts were regularly rejected earlier than the A(-) grafts. In all A(-) recipients from first-set A(+) grafts, second-set grafts from A(+) donors behaved as white grafts. No positive correlation could be found between the anti-A alloantibody titer and the precocity of the graft rejection in A(-) recipients from A(+) donors. In these same recipients there was no modification of the anti-A antibody titer after the graft.

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